Qubit energy tuner based on single flux quantum circuits

A device called the qubit energy tuner (QET), based on single flux quantum (SFQ) circuits, has been proposed for Z control of superconducting qubits. The QET is created by improving flux digital-to-analog converters (flux DACs). It can set the energy levels or frequencies of qubits, particularly flux-tunable transmons, and perform gate operations requiring Z control. The circuit structure of the QET is elucidated, consisting of an inductor loop and flux bias units for coarse or fine-tuning. The key feature of the QET is analyzed to understand how SFQ pulses change the inductor loop current, which provides external flux for qubits. Three simulations were performed to verify QET functionality. The first simulation verified the responses of the inductor loop current to SFQ pulses, showing a relative deviation of approximately 4.259% between the analytical solutions of the inductor loop current and the solutions from the WRSpice time-domain simulation. The second and third simulations, using QuTip, demonstrated how to perform a Z gate and an iSWAP gate using the QET, respectively, with corresponding fidelities of 99.99884% and 99.93906% for only one gate operation to specific initial states. These simulations indicate that the SFQ-based QET could act as an efficient component of SFQ-based quantum–classical interfaces for digital Z control of large-scale superconducting quantum computers

OHMI: The Ontology of Host-Microbiome Interactions

Host-microbiome interactions (HMIs) are critical for the modulation of biological processes and are associated with several diseases, and extensive HMI studies have generated large amounts of data. We propose that the logical representation of the knowledge derived from these data and the standardized representation of experimental variables and processes can foster integration of data and reproducibility of experiments and thereby further HMI knowledge discovery. A community-based Ontology of Host-Microbiome Interactions (OHMI) was developed following the OBO Foundry principles. OHMI leverages established ontologies to create logically structured representations of microbiomes, microbial taxonomy, host species, host anatomical entities, and HMIs under different conditions and associated study protocols and types of data analysis and experimental results

The Efficacy and Safety of Diyushengbai Tablet on Preventing and Treating Leukopenia Caused by Radiotherapy and Chemotherapy Against Tumor: A Systematic Review and Meta-Analysis

Background: Leukopenia is one of the side effects of radiotherapy and chemotherapy. Diyushengbai tablet (DYT) is used to prevent and treat leukopenia caused by various reasons. A meta-analysis was performed to systematically analyze the therapeutic effects of DYT on preventing and treating leukopenia caused by radiotherapy and chemotherapy.Objectives: This study aimed to systematically evaluate the efficacy and safety of DYT in preventing and treating leukopenia caused by radiotherapy and chemotherapy.Methods: We performed a comprehensive literature search of electronic databases such as PubMed, The Cochrane Library, China Knowledge Network (CNKI), China Biomedical Literature Database (CBM), Wanfang Data Knowledge Service Platform, and VIP, through November of 2021. The scanning reports deadline is until November 2021. The bias risk evaluation criteria developed by the Cochrane collaborative organization were used to evaluate the literature quality of the included studies. The RevMan5.4 software was used to analyze the data, and the Stata16.0 was used to perform the Egger test.Results: After selecting all the databases, a total of 41 reports which involved 3,793 cases were analyzed. Meta-analysis showed that DYT could significantly reduce the white blood cell (WBC) suppression caused by radiotherapy and chemotherapy and improve the patients’ WBC counts and neutrophils, compared with the efficacy of other oral WBC-elevating drugs such as Leucogen tablets and Batilol tablets and additional utilization of granulocyte colony-stimulating factor (G-CSF). The results of meta-analysis showed that for preventive medication purpose, the overall incidence of leukocyte suppression was [RR = 0.74, 95%CI (0.59, 0.92), p = 0.006], and the white blood cell count was [MD = 1.12, 95%CI (0.95, 1.29), p < 0.00001]; while for therapeutic purpose, the incidence of overall leukocyte suppression was [RR = 0.61, 95%CI (0.38, 0.95), p = 0.03], and the white blood cell count was [MD = 1.20, 95%CI (0.77, 1.62), p < 0.00001]. More importantly, the additional use of DYT can reduce the application amount of G-CSF. The results showed that the application of G-CSF can be reduced by an average of 1.57 from the beginning of treatment to return normal white blood cells around 2.23 in two cycles of chemotherapy.Conclusion: DYT is more effective in preventing and treating leukopenia caused by radiotherapy and chemotherapy than other oral WBC-elevating drugs, which have a high clinical value

Benchmarking the Memory Hierarchy of Modern GPUs

Part 2: Parallel and Multi-Core TechnologiesInternational audienceMemory access efficiency is a key factor for fully exploiting the computational power of Graphics Processing Units (GPUs). However, many details of the GPU memory hierarchy are not released by the vendors. We propose a novel fine-grained benchmarking approach and apply it on two popular GPUs, namely Fermi and Kepler, to expose the previously unknown characteristics of their memory hierarchies. Specifically, we investigate the structures of different cache systems, such as data cache, texture cache, and the translation lookaside buffer (TLB). We also investigate the impact of bank conflict on shared memory access latency. Our benchmarking results offer a better understanding on the mysterious GPU memory hierarchy, which can help in the software optimization and the modelling of GPU architectures. Our source code and experimental results are publicly available

The Dysbiosis of Gut Microbiota Caused by Low-Dose Cadmium Aggravate the Injury of Mice Liver through Increasing Intestinal Permeability

Cadmium (Cd), widely present in food and drinking water at low doses, can cause health risks. However, the mechanistic effects of long-term Cd exposure at low dose through dietary intake is poorly studied. The aim of this study is to elucidate whether the dysbiosis of gut microbiota caused by Cd at an environmental low dose can aggravate the injury of mice liver, and the possible mechanism is investigated. In order to explore the potential underlying mechanism, the analyses of the variation of gut microbiota composition, intestinal permeability, and hepatic transcriptome were conducted. Our results showed that gut microbiota was disturbed. The rise of intestinal permeability induced by the dysbiosis of gut microbiota resulted in more Cd ions accumulating in mice liver, but it could be restored partly through depleting gut microbiota by antibiotics cocktail. Transcriptomic analyses indicated that 162 genes were significantly differentially expressed including 59 up-regulated and 103 down-regulated in Cd treatment. These genes were involved in several important pathways. Our findings provide a better understanding about the health risks of cadmium in the environment